Tumor and host samples show distinct cytokine secretion profiles upon RG7356 treatment.

<p>(A) Cluster analysis of Luminex cytokine panel. Samples were analyzed at 8 and 168 hours after treatment in both human- and mouse-specific assays. Rows represent analytes, columns represent samples. Only analytes covered by both panels were used for clustering. Circles represent human samples, triangles represent mouse samples; open and solid symbols represent 8 and 168 hours of treatment, respectively, while color codes depict the different treatment groups. (B) and (C) Side-by-side comparison of human (left) and mouse (right) analyte concentrations (pg/ml) for the three different treatments. Shown are concentrations for GM-CSF (B) and MIP-1a (C).