<p>A key difference is the interaction of <i>Bm</i>MetRS Phe213 which is functionally equivalent to Leu456 in <i>Tb</i>MetRS but led to different protein geometry. The <i>Tb</i>MetRS structure is shown in blue and the 2 different residues in orange.</p
<p>(A) Ribbon diagram of MltR (left). The structure is colored by functional domains; red: DNA-bindi...
(A) Chains B, C, and D are superposed on chain A. For comparison PDB entry 1JPZ (chain A) with the S...
<p>A) Superpositions of the three ligand-bound dimers, emphasizing the change in relative dispositio...
<p>(A) The structure of <i>Tb</i>MetRS•<b>Chem 1433</b> is used as the prototypic complex to depict ...
<p>(A) The structure of <i>Tb</i>MetRS•<b>Chem 1433</b>•AMPPCP shown with the difference electron de...
<p>Inhibitor binding residues in <i>Bm</i>MetRS compared to <i>Tb</i>MetRS and <i>Lm</i>MetRS are hi...
<p>(A) The chemical structure of a previously reported aminoquinolone-based inhibitor (ABI) <b>Chem ...
<p>(Top) Ribbon views of Mt-trHbN, Mt-trHbO, and Cj-trHbP, including the heme-Fe group (red) and the...
<p>Dimers of (A) TM-IclR (unliganded) and (B) TraR (complexed with DNA, yellow vDW spheres), as illu...
<p>Very few differences could be observed between amino acid residues within the inhibitor binding s...
<p>(A and B) Introduction of the AYC motif results in π-stacking interactions between the chromophor...
a<p>Atom CBB is the terminal vinyl methylene carbon of pyrrole ring b, ...
<p>(<b>A</b>) MurD protein in complex with compound <b>1b</b> (PDB entry 2VTD) <a href="http://www.p...
<p>All residues within 5Å of either GDP, Mn<sup>2+</sup> or methyl-α-mannose are included in the fig...
<p>(<b>A</b>) Comparison of the dimerization interfaces of the KLHL3 and SPOP BTB domains. A single ...
<p>(A) Ribbon diagram of MltR (left). The structure is colored by functional domains; red: DNA-bindi...
(A) Chains B, C, and D are superposed on chain A. For comparison PDB entry 1JPZ (chain A) with the S...
<p>A) Superpositions of the three ligand-bound dimers, emphasizing the change in relative dispositio...
<p>(A) The structure of <i>Tb</i>MetRS•<b>Chem 1433</b> is used as the prototypic complex to depict ...
<p>(A) The structure of <i>Tb</i>MetRS•<b>Chem 1433</b>•AMPPCP shown with the difference electron de...
<p>Inhibitor binding residues in <i>Bm</i>MetRS compared to <i>Tb</i>MetRS and <i>Lm</i>MetRS are hi...
<p>(A) The chemical structure of a previously reported aminoquinolone-based inhibitor (ABI) <b>Chem ...
<p>(Top) Ribbon views of Mt-trHbN, Mt-trHbO, and Cj-trHbP, including the heme-Fe group (red) and the...
<p>Dimers of (A) TM-IclR (unliganded) and (B) TraR (complexed with DNA, yellow vDW spheres), as illu...
<p>Very few differences could be observed between amino acid residues within the inhibitor binding s...
<p>(A and B) Introduction of the AYC motif results in π-stacking interactions between the chromophor...
a<p>Atom CBB is the terminal vinyl methylene carbon of pyrrole ring b, ...
<p>(<b>A</b>) MurD protein in complex with compound <b>1b</b> (PDB entry 2VTD) <a href="http://www.p...
<p>All residues within 5Å of either GDP, Mn<sup>2+</sup> or methyl-α-mannose are included in the fig...
<p>(<b>A</b>) Comparison of the dimerization interfaces of the KLHL3 and SPOP BTB domains. A single ...
<p>(A) Ribbon diagram of MltR (left). The structure is colored by functional domains; red: DNA-bindi...
(A) Chains B, C, and D are superposed on chain A. For comparison PDB entry 1JPZ (chain A) with the S...
<p>A) Superpositions of the three ligand-bound dimers, emphasizing the change in relative dispositio...