Homology model of human mitochondrial MetRS overlaid with the crystal structure of BmMetRS in complex with 1433.

Binding of the Respiratory Chain Inhibitor Antimycin to the Mitochondrial bc1 Complex: A New Crystal Structure Reveals an Altered Intramolecular Hydrogen-Bonding Pattern

Huang, Li-shar
Cobessi, David
Tung, Eric Y.
Berry, Edward A.

May 2005

Antimycin A (antimycin), one of the first known and most potent inhibitors of the mitochondrial res...

Binding of the Respiratory Chain Inhibitor Antimycin to theMitochondrial bc1 Complex: A New Crystal Structure Reveals an AlteredIntramolecular Hydrogen-Bonding Pattern

Huang, Li-shar
Cobessi, David
Tung, Eric Y.
Berry, Edward A.

May 2005

Antimycin A (antimycin), one of the first known and most potent inhibitors of the mitochondrial resp...

The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme

Stammers, D.K.
Champness, J.N.
Beddell, C.R.
Dann, J.G.
Eliopoulos, E.
Geddes, A.J.
Ogg, D.
North, A.C.T.

June 1987

AbstractThe structure of mouse L1210 dihydrofolate reductase (DHFR) complexed with NADPH and trimeth...

Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening

Lamees Hegazy
Lauren E. Gill
Kelly D. Pyles
Christopher Kaiho
Sophia Kchouk
Brian N. Finck
Kyle S. McCommis
Bahaa Elgendy

February 2022

The mitochondrial pyruvate carrier (MPC) is an inner-mitochondrial membrane protein complex that has...

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer

Tavoulari, Sotiria
Schirris, Tom J J
Mavridou, Vasiliki
Thangaratnarajah, Chancievan
King, Martin S
Jones, Daniel T D
Ding, Shujing
Fearnley, Ian M
Kunji, Edmund R S

June 2022

OBJECTIVE: The mitochondrial pyruvate carrier (MPC) has emerged as a promising drug target for metab...

Amino acid sequence alignments within the benzyl and quinolone pocket of BmMetRS, TbMetRS and LmMetRS.

Kayode K. Ojo (353587)
Ranae M. Ranade (553497)
Zhongsheng Zhang (544722)
David M. Dranow (278419)
Janette B. Myers (2922132)
Ryan Choi (278424)
Steve Nakazawa Hewitt (2922129)
Thomas E. Edwards (9682)
Douglas R. Davies (242600)
Donald Lorimer (2922135)
Stephen M. Boyle (538761)
Lynn K. Barrett (293068)
Frederick S. Buckner (198223)
Erkang Fan (544727)
Wesley C. Van Voorhis (191219)

August 2016

Inhibitor binding residues in BmMetRS compared to TbMetRS and LmMetRS are hi...

Structures of two zinc -dependent homocysteine S -methyltransferases: Betaine -homocysteine methyltransferase and cobalamin -dependent methionine synthase.

Evans, John Charles

January 2004

Homocysteine (Hcy) has been identified as an independent risk factor for a variety of health problem...

Human mitochondrial branched chain aminotransferase: Structural basis for substrate specificity and role of redox active cysteines

Conway, Myra E.
Wallin, Reidar
Poole, Leslie B.
Hutson, Susan M.
Yennawar, Neela

April 2003

Crystal structures of the fold type IV pyridoxal phosphate (PLP)-dependent human mitochondrial branc...

Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection

Koh, Cho Yeow
Kim, Jessica E.
Shibata, Sayaka
Ranade, Ranae M.
Yu, Mingyan
Liu, Jiyun
Gillespie, J. Robert
Buckner, Frederick S.
Verlinde, Christophe L.M.J.
Fan, Erkang
Hol, Wim G.J.

October 2012

SummaryTo guide development of new drugs targeting methionyl-tRNA synthetase (MetRS) for treatment o...

Crystal structure of BmMetRS in-complex with selenomethione and three different inhibitors to define structural pockets.

Kayode K. Ojo (353587)
Ranae M. Ranade (553497)
Zhongsheng Zhang (544722)
David M. Dranow (278419)
Janette B. Myers (2922132)
Ryan Choi (278424)
Steve Nakazawa Hewitt (2922129)
Thomas E. Edwards (9682)
Douglas R. Davies (242600)
Donald Lorimer (2922135)
Stephen M. Boyle (538761)
Lynn K. Barrett (293068)
Frederick S. Buckner (198223)
Erkang Fan (544727)
Wesley C. Van Voorhis (191219)

August 2016

The binding of each ligand; selenomethionine (Fig 4a), 1312 (Fig 4b), 1415 (Fig 4c)...

The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme.

Stammers, DK
Champness, JN
Beddell, CR
Dann, JG
Eliopoulos, E
Geddes, AJ
Ogg, D
North, AC

June 1987

The structure of mouse L1210 dihydrofolate reductase (DHFR) complexed with NADPH and trimethoprim ha...

A superposition of BmMetRS (PDB ID 4PLY2 Chain B) and TbMetRS (PDB ID 4MVW Chain) bound to compound 1433.

Kayode K. Ojo (353587)
Ranae M. Ranade (553497)
Zhongsheng Zhang (544722)
David M. Dranow (278419)
Janette B. Myers (2922132)
Ryan Choi (278424)
Steve Nakazawa Hewitt (2922129)
Thomas E. Edwards (9682)
Douglas R. Davies (242600)
Donald Lorimer (2922135)
Stephen M. Boyle (538761)
Lynn K. Barrett (293068)
Frederick S. Buckner (198223)
Erkang Fan (544727)
Wesley C. Van Voorhis (191219)

August 2016

A key difference is the interaction of BmMetRS Phe213 which is functionally equivalent to ...

Topology of human methionine S-adenosyltransferase

Khedkar, Santosh A
Malde, Alpeshkumar K
Coutinho, Evans C

January 2006

138-145Insights into the three-dimensional (3D) structure of the enzyme, Methionine S-adenosyltrans...

Characterization of inhibitor binding sites of mitochondrial complex I using fluorescent inhibitor

Ino, Takara
Nishioka, Takaaki
Miyoshi, Hideto

August 2003

AbstractRecent progress in complex I research suggests that a wide variety of complex I inhibitors s...

Structurally diverse mitochondrial branched chain aminotransferase (BCATm) leads with varying binding modes identified by fragment screening

Borthwick, Jennifer A.
Ancellin, Nicolas
Bertrand, Sophie M.
Bingham, Ryan P.
Carter, Paul S.
Chung, Chun-wa
Churcher, Ian
Dodic, Nerina
Fournier, Charlène
Francis, Peter L.
Hobbs, Andrew
Jamieson, Craig
Pickett, Stephen D.
Smith, Sarah E.
Somers, Donald O'N.
Spitzfaden, Claus
Suckling, Colin J.
Young, Robert J.

March 2016

Inhibitors of mitochondrial branched chain aminotransferase (BCATm), identified using fragment scree...

Binding of the Respiratory Chain Inhibitor Antimycin to the Mitochondrial bc1 Complex: A New Crystal Structure Reveals an Altered Intramolecular Hydrogen-Bonding Pattern

Huang, Li-shar
Cobessi, David
Tung, Eric Y.
Berry, Edward A.

May 2005

Antimycin A (antimycin), one of the first known and most potent inhibitors of the mitochondrial res...

Binding of the Respiratory Chain Inhibitor Antimycin to theMitochondrial bc1 Complex: A New Crystal Structure Reveals an AlteredIntramolecular Hydrogen-Bonding Pattern

Huang, Li-shar
Cobessi, David
Tung, Eric Y.
Berry, Edward A.

May 2005

Antimycin A (antimycin), one of the first known and most potent inhibitors of the mitochondrial resp...

The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme

Stammers, D.K.
Champness, J.N.
Beddell, C.R.
Dann, J.G.
Eliopoulos, E.
Geddes, A.J.
Ogg, D.
North, A.C.T.

June 1987

AbstractThe structure of mouse L1210 dihydrofolate reductase (DHFR) complexed with NADPH and trimeth...

Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening

Lamees Hegazy
Lauren E. Gill
Kelly D. Pyles
Christopher Kaiho
Sophia Kchouk
Brian N. Finck
Kyle S. McCommis
Bahaa Elgendy

February 2022

The mitochondrial pyruvate carrier (MPC) is an inner-mitochondrial membrane protein complex that has...

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer

Tavoulari, Sotiria
Schirris, Tom J J
Mavridou, Vasiliki
Thangaratnarajah, Chancievan
King, Martin S
Jones, Daniel T D
Ding, Shujing
Fearnley, Ian M
Kunji, Edmund R S

June 2022

OBJECTIVE: The mitochondrial pyruvate carrier (MPC) has emerged as a promising drug target for metab...

Amino acid sequence alignments within the benzyl and quinolone pocket of BmMetRS, TbMetRS and LmMetRS.

Kayode K. Ojo (353587)
Ranae M. Ranade (553497)
Zhongsheng Zhang (544722)
David M. Dranow (278419)
Janette B. Myers (2922132)
Ryan Choi (278424)
Steve Nakazawa Hewitt (2922129)
Thomas E. Edwards (9682)
Douglas R. Davies (242600)
Donald Lorimer (2922135)
Stephen M. Boyle (538761)
Lynn K. Barrett (293068)
Frederick S. Buckner (198223)
Erkang Fan (544727)
Wesley C. Van Voorhis (191219)

August 2016

Inhibitor binding residues in BmMetRS compared to TbMetRS and LmMetRS are hi...

Structures of two zinc -dependent homocysteine S -methyltransferases: Betaine -homocysteine methyltransferase and cobalamin -dependent methionine synthase.

Evans, John Charles

January 2004

Homocysteine (Hcy) has been identified as an independent risk factor for a variety of health problem...

Human mitochondrial branched chain aminotransferase: Structural basis for substrate specificity and role of redox active cysteines

Conway, Myra E.
Wallin, Reidar
Poole, Leslie B.
Hutson, Susan M.
Yennawar, Neela

April 2003

Crystal structures of the fold type IV pyridoxal phosphate (PLP)-dependent human mitochondrial branc...

Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection

Koh, Cho Yeow
Kim, Jessica E.
Shibata, Sayaka
Ranade, Ranae M.
Yu, Mingyan
Liu, Jiyun
Gillespie, J. Robert
Buckner, Frederick S.
Verlinde, Christophe L.M.J.
Fan, Erkang
Hol, Wim G.J.

October 2012

SummaryTo guide development of new drugs targeting methionyl-tRNA synthetase (MetRS) for treatment o...

Crystal structure of BmMetRS in-complex with selenomethione and three different inhibitors to define structural pockets.

Kayode K. Ojo (353587)
Ranae M. Ranade (553497)
Zhongsheng Zhang (544722)
David M. Dranow (278419)
Janette B. Myers (2922132)
Ryan Choi (278424)
Steve Nakazawa Hewitt (2922129)
Thomas E. Edwards (9682)
Douglas R. Davies (242600)
Donald Lorimer (2922135)
Stephen M. Boyle (538761)
Lynn K. Barrett (293068)
Frederick S. Buckner (198223)
Erkang Fan (544727)
Wesley C. Van Voorhis (191219)

August 2016

The binding of each ligand; selenomethionine (Fig 4a), 1312 (Fig 4b), 1415 (Fig 4c)...

The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme.

Stammers, DK
Champness, JN
Beddell, CR
Dann, JG
Eliopoulos, E
Geddes, AJ
Ogg, D
North, AC

June 1987

The structure of mouse L1210 dihydrofolate reductase (DHFR) complexed with NADPH and trimethoprim ha...

A superposition of BmMetRS (PDB ID 4PLY2 Chain B) and TbMetRS (PDB ID 4MVW Chain) bound to compound 1433.

Kayode K. Ojo (353587)
Ranae M. Ranade (553497)
Zhongsheng Zhang (544722)
David M. Dranow (278419)
Janette B. Myers (2922132)
Ryan Choi (278424)
Steve Nakazawa Hewitt (2922129)
Thomas E. Edwards (9682)
Douglas R. Davies (242600)
Donald Lorimer (2922135)
Stephen M. Boyle (538761)
Lynn K. Barrett (293068)
Frederick S. Buckner (198223)
Erkang Fan (544727)
Wesley C. Van Voorhis (191219)

August 2016

A key difference is the interaction of BmMetRS Phe213 which is functionally equivalent to ...

Topology of human methionine S-adenosyltransferase

Khedkar, Santosh A
Malde, Alpeshkumar K
Coutinho, Evans C

January 2006

138-145Insights into the three-dimensional (3D) structure of the enzyme, Methionine S-adenosyltrans...

Characterization of inhibitor binding sites of mitochondrial complex I using fluorescent inhibitor

Ino, Takara
Nishioka, Takaaki
Miyoshi, Hideto

August 2003

AbstractRecent progress in complex I research suggests that a wide variety of complex I inhibitors s...

Structurally diverse mitochondrial branched chain aminotransferase (BCATm) leads with varying binding modes identified by fragment screening

Borthwick, Jennifer A.
Ancellin, Nicolas
Bertrand, Sophie M.
Bingham, Ryan P.
Carter, Paul S.
Chung, Chun-wa
Churcher, Ian
Dodic, Nerina
Fournier, Charlène
Francis, Peter L.
Hobbs, Andrew
Jamieson, Craig
Pickett, Stephen D.
Smith, Sarah E.
Somers, Donald O'N.
Spitzfaden, Claus
Suckling, Colin J.
Young, Robert J.

March 2016

Inhibitors of mitochondrial branched chain aminotransferase (BCATm), identified using fragment scree...

Binding of the Respiratory Chain Inhibitor Antimycin to the Mitochondrial bc1 Complex: A New Crystal Structure Reveals an Altered Intramolecular Hydrogen-Bonding Pattern

Huang, Li-shar
Cobessi, David
Tung, Eric Y.
Berry, Edward A.

May 2005

Antimycin A (antimycin), one of the first known and most potent inhibitors of the mitochondrial res...

Binding of the Respiratory Chain Inhibitor Antimycin to theMitochondrial bc1 Complex: A New Crystal Structure Reveals an AlteredIntramolecular Hydrogen-Bonding Pattern

Huang, Li-shar
Cobessi, David
Tung, Eric Y.
Berry, Edward A.

May 2005

Antimycin A (antimycin), one of the first known and most potent inhibitors of the mitochondrial resp...

The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme

Stammers, D.K.
Champness, J.N.
Beddell, C.R.
Dann, J.G.
Eliopoulos, E.
Geddes, A.J.
Ogg, D.
North, A.C.T.

June 1987

AbstractThe structure of mouse L1210 dihydrofolate reductase (DHFR) complexed with NADPH and trimeth...

Homology model of human mitochondrial MetRS overlaid with the crystal structure of <i>Bm</i>MetRS in complex with 1433.

Abstract

Extracted data

Topics

Homology model of human mitochondrial MetRS overlaid with the crystal structure of <i>Bm</i>MetRS in complex with 1433.

Abstract

Extracted data

Topics

Related items

Related items