MPR300 is decreased in human brain from patients with early PD.

<p>WB of MPR300 and α-syn in SDS-soluble protein lysates generated from the anterior cingulate cortex of 6 autopsy-confirmed patients with Braak Lewy body stage 4 (PD) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0160501#pone.0160501.ref065" target="_blank">65</a>] versus 9 controls as detailed in the table below reporting their demographic details. Immunoblot data was normalized to β-actin and a multivariate analysis performed to determine if MPR300 or α-syn were changed in PD. Age and post-mortem delay were included as covariates. The results show a significant reduction in MPR300 protein and an expected significant increase in α-syn levels in PD anterior cingulate cortex. Values are given as mean ± SEM and * = p<0.05.