Influence of <i>HspB1</i> gene invalidation on muscle fibre characteristics.

<p>(A, B) Frequency profiles of muscle fibre cross sectional area at 12 weeks of age in the m. <i>Soleus</i> (A) and the m. <i>Tibialis anterior</i> (B). (C-F) Myosin heavy chain (MyHC) immunostaining in the m. <i>Soleus</i> (C, D, BAD5 staining) and m. <i>Tibialis anterior</i> (E, F, BF-F3 immuno-staining) at 12 weeks of age. (C, E) wild type controls; (D, F) <i>HspB1</i>^-/- mice. Fibre types: I, slow oxidative fibre; IIA and IIX, fast oxido-glycolytic fibre; IIB, fast glycolytic fibre. <i>Scale bar</i>: <i>50 μm</i>; (G) electrophoretic separation of MyHC at 3 ages in wild type controls (<i>HspB1</i>^+/+) and <i>HspB1</i>^-/- mutant mice.