Elucidating the Activation Mechanism of the Insulin-Family Proteins with Molecular Dynamics Simulations - Fig 9

<p><b>Strongest hydrogen bonds between the upper flank of the C loop and its lower flank and/or A domain in (A) IGF-I and (B) IGF-II.</b> The hydrogen bonds are from left to right, (A) K27(N)-T41(O) and F25(O)-I43(N), and (B) R30(O)-S39(N), R30(N)-S39(O) and F28(O)-G41(N).