Radial distributions of the microvascular density, <i>MVD</i>, and the relative blood volume, <i>rBV</i>.

<p>The simulation box was divided in 100 <i>μm</i> thick concentric shells over which the regional <i>MVD</i> and <i>rBV</i> were determined to obtain radial profiles depending on the distance from the center |<i>x</i>|. Plotted is the ensemble mean of these profiles, where the error bars display the standard deviation (STD). As can be seen, a compartmentalization into varying degrees of vascularization (<i>MVD</i>) and vascular dilatation (<i>rBV</i>) exist which is typical for Melanoma [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161267#pone.0161267.ref056" target="_blank">56</a>] and Glioma [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161267#pone.0161267.ref057" target="_blank">57</a>]. Fig 4 provides evidence that these features are also present in breast tumors. The STD of <i>MVD</i> further shows that the <i>MVD</i> of the tumor core is below normal in most realizations of the ensemble which conforms to our expectations for tumors. Oscillations are an artifact of the confinement of the vessels to a lattice.