DENV virus infection induces differential expression of selected protein classes.

<p>(<b>A</b>) Comparison of 4,907 log₂ DENV/Mock host protein abundance ratios between replicate experiments (R1 and R2). Black dots, proteins that were quantified with < 50% variance between replicates. (<b>B</b>) Comparison of log₁₀ relative abundances of all host proteins (grey circles) to proteins annotated in the Transporter (blue circles, N = 209), RNA binding (yellow circles, N = 522), and ubiquitin proteasome pathway (orange circles, N = 44). Abundance ratios are plotted in increasing magnitude and expressed as a fraction of the total number of proteins. (<b>C</b>) Reactome functional interaction networks of proteins annotated in the transporter PANTHER protein class ontology. Four sub-networks (≥ 3 proteins per network) containing 71 proteins were formed. Nodes labeled with gene symbols and colored by relative log2 protein abundance. Clusters are labeled with representative transporter classes.