Additional file 8: Figure S5. of Recombination-driven generation of the largest pathogen repository of antigen variants in the protozoan Trypanosoma cruzi

Architecture of Model TcTS and Mapped to 1S0I_A Crystal Structure. The model TcTS architecture (starting with the signal peptide motifs) is depicted. Each box represents an individual motif from the MEME analysis and is based on the alignment of motifs in Additional file 4: Table S4a. The top number is the motif number, the middle percentage is the representation of that motif across all TcTS sequences (including where absent), and the bottom number is the representation of that motif in TcTS sequences of length >2000b. Motifs not mapped to crystal structure are color-coded white (either not part of crystal, like the signal peptide, or the sequence homology was not high enough to constitute a match). Otherwise, frequent motifs (>1000 occurrences in all TcTS sequences) are color-coded red, while less frequent motifs are blue. The highly-variable C-terminal region containing multiple motifs is represented as a black box. Note that motif 44 (in yellow) is homologous to 1S0I_A and is shown; in the model TcTS architecture this position is occupied by motif 26. Locations of previously characterized TcTS motifs and residues are also shown. (TIF 970 kb