Identification of the N+1 consensus sequence.

<p>(A) Correlation between 10 bp long dinucleotide patterns composed of one copy of each SS, WW, YY and RR dinucleotides and 2 Ns evaluated on human genomic nucleosomes and the N+1 nucleosome; each dot represents the strength of the 10 bp frequency of a consensus sequence in the N+1 region or in genomic nucleosome regions (defined by MNase-seq data); green and red dots mark two classes of patterns (circular permutations of SS-RR-WW-YY and SS-YY-WW-RR, respectively) that are known to have high nucleosomes affinities [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005144#pcbi.1005144.ref047" target="_blank">47</a>]. (B) Comparative analysis of representative consensus sequence strength in 5 organisms on genomic nucleosomes (left panel, Genomic) and promoter nucleosomes (right panel, N+1). Each square represents the strength of a 10 bp periodic signal for a consensus sequence (rows) for an organism (columns). Hs: <i>H</i>. <i>sapiens</i>, Mm: <i>M</i>. <i>musculus</i>, Dr: <i>D</i>. <i>rerio</i>, Dm: <i>D</i>. <i>melanogaster</i> and Ce: <i>C</i>. <i>elegans</i>. A comparative analysis of all motifs tested can be found in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005144#pcbi.1005144.s007" target="_blank">S6</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005144#pcbi.1005144.s008" target="_blank">S7</a> Figs (C) Correlation analysis as performed in A for <i>C</i>. <i>elegans</i> promoters and genomic nucleosomes.