Associations between serum creatinine concentration, creatinine-based estimated glomerular filtration rate [eGFR(crea)], serum cystatin C concentration or cystatin C-based eGFR [eGFR(cys)] and serum angiopoietin-2 (Ang-2) concentration in the SHIP-1 population.

<p>For each exposure left side: Estimated mean serum Ang-2 with 95% confidence intervals (CI) by sex-specific quartiles of exposure calculated by analysis of variance adjusted for age, sex and waist circumference. Right side: linear regression line with 95% CI (grey shaded area). Linear regression models with restricted cubic splines were adjusted for age, sex, waist circumference, smoking, total cholesterol, systolic and diastolic blood pressure and additionally in the whole population for diabetes mellitus type 2 and use of antihypertensive medication.