The average order of CHOL molecules in the lipid headgroup region of the upper and lower leaflets next to the inactive receptors (top) and activated receptors (bottom) during the final 2 μs of the low receptor density simulations with the backbone beads kept fixed.

<p>In both cases, the white color is set to the average value of the simulations with the inactive receptors. The center of mass of the seven TM helices are indicated by the colored dots as follows: TMs 1 through 7 are colored in blue, red, grey, orange, yellow, green, and pink.