The lncRNAUCA1 promotes Wnt signaling activity by facilitating β-catenin cyto-nuclear translocation.

<p>Shown are immunocytochemistry staining for the localization of β-catenin in MCF-7-R (A) and T47D-R (B) cells transfected with scramble control or si-UCA1. Meganification, 400×. (C) Western blot assay shows the decreased β-catenin protein level in the nuclear fraction from cells transfected with si-UCA1. Nuclear Lamin B serves as the loading control. (D) TOP/FOP assay showing the decreased activity of Wnt signaling in the tamoxifen-resistant breast cancer cells when UCA1 was knockdown. *, <i>P</i><0.05.