During Wnt stimulation, β-catenin accumulates in the nucleus, where it regulates gene transcription. In this issue of Developmental Cell, Lu et al. (2015) report a mechanism that specifically targets this nuclear pool for degradation, using lysine demethylation as ubiquitination signal
Nuclear activation of Wnt/β-catenin signaling is required for cell proliferation in inflammation and...
The highly conserved Wnt signalling pathway plays an important role in embryonic development and dis...
Wnt proteins comprise one family of secreted signaling molecules that is conserved in a wide range o...
During Wnt stimulation, β-catenin accumulates in the nucleus, where it regulates gene transcription....
β-Catenin plays a dual role as an adhesion molecule in adherens junctions at the plasma membrane and...
SummaryIn the absence of Wnt activation, cytosolic β-catenin is degraded through GSK3/CK1-mediated p...
The control of β-catenin levels is vital to the cell. The primary means of regulation is through ubi...
The canonical Wnt signaling pathway has been the focus of intensive research because of its frequent...
SummaryTwo manuscripts published recently in Cell Stem Cell (Lluis et al., 2008 [this issue]; Marson...
The canonical Wnt signaling pathway has been the focus of intensive research because of its frequent...
beta-catenin-mediated Wnt signaling is an ancient cell-communication pathway in which beta-catenin d...
Canonical Wnt signaling is repeatedly used during development to control cell fate, and it is often ...
SummaryTreatment with several Wnt/β-catenin signaling pathway regulators can change the cellular rep...
Treatment with several Wnt/β-catenin signaling pathway regulators can change the cellular reprogramm...
Summary: Despite extensive research on the canonical Wnt signaling pathway, the mechanism by which t...
Nuclear activation of Wnt/β-catenin signaling is required for cell proliferation in inflammation and...
The highly conserved Wnt signalling pathway plays an important role in embryonic development and dis...
Wnt proteins comprise one family of secreted signaling molecules that is conserved in a wide range o...
During Wnt stimulation, β-catenin accumulates in the nucleus, where it regulates gene transcription....
β-Catenin plays a dual role as an adhesion molecule in adherens junctions at the plasma membrane and...
SummaryIn the absence of Wnt activation, cytosolic β-catenin is degraded through GSK3/CK1-mediated p...
The control of β-catenin levels is vital to the cell. The primary means of regulation is through ubi...
The canonical Wnt signaling pathway has been the focus of intensive research because of its frequent...
SummaryTwo manuscripts published recently in Cell Stem Cell (Lluis et al., 2008 [this issue]; Marson...
The canonical Wnt signaling pathway has been the focus of intensive research because of its frequent...
beta-catenin-mediated Wnt signaling is an ancient cell-communication pathway in which beta-catenin d...
Canonical Wnt signaling is repeatedly used during development to control cell fate, and it is often ...
SummaryTreatment with several Wnt/β-catenin signaling pathway regulators can change the cellular rep...
Treatment with several Wnt/β-catenin signaling pathway regulators can change the cellular reprogramm...
Summary: Despite extensive research on the canonical Wnt signaling pathway, the mechanism by which t...
Nuclear activation of Wnt/β-catenin signaling is required for cell proliferation in inflammation and...
The highly conserved Wnt signalling pathway plays an important role in embryonic development and dis...
Wnt proteins comprise one family of secreted signaling molecules that is conserved in a wide range o...
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