IL-37 suppresses inflammatory responses in mycobacterial-infected macrophages and mice.

<p><b>(A- B)</b> ELISA detection of IL-6 <b>(A)</b> and TNF-α <b>(B)</b> in WT and IL-37-Tg macrophages infected with H37Rv at MOI = 5 for indicated times. Results are the mean±SEM and representative of 3 independent experiments with triplicates each. <b>(C-D)</b> Kinetics of IL-6 <b>(C)</b> and TNF-α <b>(D)</b> production detected by ELISA in the lung of WT and IL-37-Tg mice infected with BCG. Results are the mean±SEM and are pooled from two independent experiments. n = 7 or 8 for each time point; two way ANOVA with Bonferroni’s post test. *, p<0.05; **, p<0.01.