Comparison of antiviral antibody kinetics following SIV and RhCMV infection.

<p>(<b>A</b>) Plasma titers of anti-SIV gp130 and p27 IgG during SIV infection are shown. Changes in anti-SIV p27 avidity indices post SIV infection are shown on the right. (<b>B</b>) SIV infection impairs RhCMV-specific humoral immune responses. (<b>C</b>) Changes in plasma anti-RhCMV IgG titers and avidity indices are noted during primary RhCMV infection. (<b>D</b>) Correlation of SM and AM B cell frequencies in PBMC of SIV-infected macaques with plasma antibody titers of anti-SIV gp130 was determined. Statistical analyses of avidities indices were performed using Student’s <i>t</i> tests (paired, two-tailed). Correlation analyses were performed by Spearman’s rank tests. Symbol: *** <i>P</i> < 0.001. ns: not significant.