Contrasting relationships between viral loads and Type I IFN levels during acute and chronic SIV infection.

<p>(A) Plasma IFNα during pathogenic SIV infection as measured by a modified Luminex assay. (B) Plasma SIV viral load was determined by PCR (dashed line indicates assay detection limit) (C) CD4+ T cell counts during the acute and chronic stages of SIV infection. Spearman's rho correlations shown between plasma IFNα levels and viral loads during (D) acute and (E) chronic SIV infection of rhesus macaques. (F) Spearman's rho correlations shown between IFNα expression and CD4+ T cell counts in chronic SIV infection. Measurements are shown for SIV-infected rhesus macaques (n = 10).