Additional file 1: Figure S1. of Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts

Source data for Chrom3D modeling. Figure S2. Hi-C and LMNA constraints integrated in Chrom3D. Figure S3. Chromosome moves introduced in the Chrom3D modeling framework. Figure S4. Structure characteristics. Figure S5. Correlation analysis between interaction frequency matrices reconstructed from 400 modeled structures and matrices from input Hi-C data. Figure S6. Chrom3D and IMP comparison. Figure S7. Chrom3D modeling of the ENm008 ENCODE region containing the Îą-globin locus. Figure S8. Stability of TADs at the nuclear periphery as a function of TAD size, across 400 structures. Figure S9. FISH validation of radial TAD placement predicted by Chrom3D. Figure S10. Expression of Flag-LMNA wt, Flag-LMNA(R388P), and Flag-LMNA(L647R) in HeLa cells. Figure S11. LMNA LADs in FPLD patient and control fibroblasts. Table S1. FISH probe information. Table S2. Top 10 enriched GO terms for genes in LADs specific to control or FPLD patient fibroblasts. Table S3. ChIP-qPCR primers and genomic location of amplicons. (PDF 2914 kb