Different endo- and exocytosis inhibitors do not affect adhesion properties of human T lymphocytes.

<p>(<b>A</b>-<b>D</b>) Analysis of static adhesion of primary human resting CD4⁺ T cells to either ICAM-1-Fc or VCAM-1-Fc following treatment of the cells with different endo- or exocytosis inhibitors. If indicated, cells were stimulated with 50ng/ml PMA. 45min after seeding, the total number of adherent cells per mm² was quantified. Endocytosis was inhibited by adding (<b>A</b>, n = 3) chlorpromazine or (<b>B</b>, n = 3) monodansylcadaverine. Exocytosis was inhibited by adding (<b>C</b>, n = 3) brefeldin A or (<b>D</b>, n = 3) Exo1. Mean +SEM, ns means not significant.