Renal pathological changes and changes in renal function after renal IRI.

<p>(A) Varying degrees of renal pathological changes from 1 h to 24 h after reperfusion in the IRI groups, including loss of brush borders, vacuolar degeneration and necrosis in epithelial cells, dilatation, cast formation, and cell debris in the kidney tubules. Arrow denotes pathological change of the renal tissue. The control group displayed normal histology. (B) SCr and (C) BUN levels were significantly elevated in the IRI groups compared with levels in the control group, and both SCr and BUN were time-dependently elevated from 1 h to 24 h after reperfusion in the IRI groups. Kidney sections were stained with hematoxylin and eosin. Original magnification, X200. The data are presented as the means ± standard deviation. * P <0.05, compared to control group; n = 6 in each group. IRI: ischemia/reperfusion injury.