Modeling membrane potential oscillations in male and female TRPM8 TRG neurons at 30° and 18°C.

<p>The modified Nernst equation presented in the methods was used to simulate membrane potentials. The value n was set to 13 in the model for this figure. However, similar results were obtained with all values of n > 5. (A) In female neurons the cooler temperature reduces both I_k and I_h resulting in a lower frequency and larger fluctuations in membrane potential. The graphs to the right of the traces are plots of the conductances used in the lookup table for the model. (B) In male neurons I_h is reduced at cool temperatures while I_k remains unaffected, resulting in a net suppression of membrane oscillations. The graphs to the right of the traces are plots of the conductances used in the lookup table for the model.