Macroscopic and kinetic characteristics of the mutant LTCC.

<p>(A) Representative whole-cell Ca²⁺ currents recorded from HEK293T cells transfected with WT or Q1916R mutation. Currents were elicited with the pulse protocol illustrated in the inset. (B) Current-voltage relationship for WT (n = 28) and Q1916R (n = 17) calcium channels. The peak Q1916R mutant <i>I</i>_Ca at 0 mV was decreased by 60%, when compared with the WT <i>I</i>_Ca; values are the means ± SEMs (*<i>P</i><0.05, **<i>P<</i>0.01). (C-D) The voltage-dependence of steady state activation (SSA) and steady state inactivation (SSI) did not significantly differ between the WT and Q1916R calcium channels.