Cardiac whole-cell L-type calcium currents.

<p>Representative original current traces obtained at different test potentials (A) and IV-curves (B) reveal an increase of calcium current in ventricular myocytes from mice lacking Gα_i3 and a decrease in mice lacking Gα_i2 as compared to WT mice. (C) Steady-state inactivation of Gα_i2^−/− (n = 11) is shifted to more negative voltages as compared to Gα_i3^−/− (n = 13, p<0.05) and WT (n = 18, p<0.05). (D) A slowing of the recovery time constant τ is found in cardiomyocytes from Gα_i2^−/− mice (287±21 ms, n = 9) as compared to Gα_i3^−/− cells (n = 9) and WT (n = 16).