TDP-43 domain structure with caspase and calpain cleavage sites.

<p>(A) Schematic of the full-length, 414 amino acid long TDP-43 protein. NLS = nuclear localization signal, RRM1/RRM2 = RNA recognition motifs, NES = nuclear export signal. The A90V variant and the M337V mutation are indicated in red. CS = (putative) caspase cleavage site, CL = (putative) calpain cleavage site. (B) Table of TDP-43 caspase and calpain cleavage sites described in the literature.