Comparison of the molecular binding activities (M.B.A.) of Chk, Csk-Chk chimera and Csk. The M.B.A. values of Chk, Csk-Chk Chimera and Csk were plotted against at the designated concentrations used in the surface plasmon resonance spectroscopic analysis of the kinetics of their binding to the immobilised Hck (2PA-YEEI) (Figs. 4 and 5). Calculation of the M.B.A. values was presented in Additional file 8: Table S1. (TIFF 309Â kb
Protein tyrosine kinases (PTKs) are important signal transducers. Most PTKs have a catalytic domain,...
Protein phosphorylation, enzymatic transfer of γ-phosphate of adenosine triphosphate to a hydroxyl g...
Src family protein tyrosine kinases are involved in the regulation of a large number of cellular pro...
Kinetic analysis of phosphorylation of Chk/Csk-optimal peptide by Chk (R276A), Chk (R278A), Chk (R28...
Lineweaver-Burk plots of the rates of phosphorylation of the Csk/Chk-optimal peptide by Csk and Chk....
Key residues involved in electrostatic and hydrophobic interactions at the Src-Csk interface and rec...
Identification of tryptic fragments derived from Src co- immunoprecipitated with Chk-GFP from the DL...
Csk family contains two protein tyrosine kinases: Csk (C-terminal Src kinase) and Chk (Csk homologou...
Putative tertiary modelling of CsPK. K+ and Mg2+ ions are shown as grey and black spheres, respectiv...
BACKGROUND: C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inh...
Published: June 23, 2011C-Terminal Src kinase-homologous kinase (CHK) exerts its tumor suppressor fu...
Signaling networks are vital to the proper functioning and survival of the cell and the organism. Sr...
Figure S5. Chou-Talalay analysis: A combination of Wee1 and Chk inhibitors synergistically inhibits ...
C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK) are endogenous inhibitors constraining t...
Tree showing the relationships found between various groups using core domains. A) EPK tree of all h...
Protein tyrosine kinases (PTKs) are important signal transducers. Most PTKs have a catalytic domain,...
Protein phosphorylation, enzymatic transfer of γ-phosphate of adenosine triphosphate to a hydroxyl g...
Src family protein tyrosine kinases are involved in the regulation of a large number of cellular pro...
Kinetic analysis of phosphorylation of Chk/Csk-optimal peptide by Chk (R276A), Chk (R278A), Chk (R28...
Lineweaver-Burk plots of the rates of phosphorylation of the Csk/Chk-optimal peptide by Csk and Chk....
Key residues involved in electrostatic and hydrophobic interactions at the Src-Csk interface and rec...
Identification of tryptic fragments derived from Src co- immunoprecipitated with Chk-GFP from the DL...
Csk family contains two protein tyrosine kinases: Csk (C-terminal Src kinase) and Chk (Csk homologou...
Putative tertiary modelling of CsPK. K+ and Mg2+ ions are shown as grey and black spheres, respectiv...
BACKGROUND: C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inh...
Published: June 23, 2011C-Terminal Src kinase-homologous kinase (CHK) exerts its tumor suppressor fu...
Signaling networks are vital to the proper functioning and survival of the cell and the organism. Sr...
Figure S5. Chou-Talalay analysis: A combination of Wee1 and Chk inhibitors synergistically inhibits ...
C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK) are endogenous inhibitors constraining t...
Tree showing the relationships found between various groups using core domains. A) EPK tree of all h...
Protein tyrosine kinases (PTKs) are important signal transducers. Most PTKs have a catalytic domain,...
Protein phosphorylation, enzymatic transfer of γ-phosphate of adenosine triphosphate to a hydroxyl g...
Src family protein tyrosine kinases are involved in the regulation of a large number of cellular pro...