Additional file 1: Figure S1. of Identification and classification of small molecule kinases: insights into substrate recognition and specificity

Tree showing the relationships found between various groups using core domains. A) EPK tree of all human kinases showing major groups and their relationships. Each group is given a distinct color. As can be seen from the tree, each major group clusters together with the exception of DYRKs and CMGCs, which are part of the same group. B) PI3K tree using representative sequences belonging to each major PI3K sub group. The Inositol binding PI3Ks and protein binding PI3Ks (mTOR, SMG1, ATR and ATM) cluster separately, as expected. (PNG 161 kb