<i>CHOP</i>^<i>-/-</i> mice are resistant to <i>Hc</i> infection.

<p><b>(A)</b> C57BL/6 and <i>CHOP</i>^<i>-/-</i> mice were mock infected (uninf) or infected with 1x10⁶ <i>Hc</i> yeast and the percentage of apoptotic (viability dye⁺ and caspase-3/7⁺) alveolar macrophages (CD45⁺ SiglecF⁺ CD11b^mid CD11c⁺ F4/80⁺) was measured at 3 dpi. *p<0.05, as determined by ANOVA. (B) CFUs from lungs and spleens of C57BL/6 and CHOP-/- mice infected with 3 x 10⁵ <i>Hc</i> yeast. *p<0.05, **p<0.005, as determined by independent 1-way ANOVA analyses of log transformed CFUs at each time point. (C) Kaplan-Meier survival curves of C57BL/6 and <i>CHOP</i>^-/- mice mock infected (uninf; n = 2) or infected with 1 x 10⁶ <i>Hc</i> yeast (n = 11). *p<0.05, logrank test.