Chemical-genetic inhibition of Tec rescues mice from fatal fungal sepsis.

<p>(<b>a</b>) Survival of mice after intraperitoneal infection with 5.10⁷ CfUs of <i>C. albicans</i> and oral treatment with PCI-32765 with daily doses as indicated; treatment was stopped after 5 days; for analysis of mouse survival curves Log-rank (Mantle-Cox) test was used. n = 9 per group. (<b>b</b>) Survival of mice after intraperitoneal infection with 5.10⁷ CfUs of <i>C. albicans</i> and oral treatment with 5 mg/kg bodyweight PCI-32765 with daily doses; for analysis of mouse survival curves Log-rank (Mantle-Cox) test was used. n = 6 per group. (<b>c</b>) Survival of mice after intraperitoneal infection with 5.10⁷ CfUs of <i>C. albicans</i> and oral treatment with 5 mg/kg bodyweight PCI-32765 with daily doses; treatment was stopped after 9 days; for analysis of mouse survival curves Log-rank (Mantle-Cox) test was used. n = 6 per group.