The influence of incomplete sampling on parameter estimation.

<p>(<b>A</b>) Schematic depicting the problem of incomplete sampling: Only a fraction of the labelled cells is sampled and can be used for analysis. (<b>B</b>) Panels show the distribution of the estimated proliferation, <i>ρ</i>, and death rate, <i>δ</i>, for the homoeostatic system shown in (<b>A</b>) using the shared (<i>blue</i>) and unique (<i>orange</i>) labelling approach given different sampling fractions. (<b>C</b>) The distribution of the estimated parameters for the complex expansion dynamics analogous to (<b>B</b>). Every boxplot is based on the results of 100 individual stochastic simulations. Parameters used to simulate the dynamics and the time point of sampling are defined as before. Red lines indicate the true parameter values.