Indices of Inborn Immunity (TLR2, Interleukins 1 β and 10) in Cases of Pneumonia among Newborn Infants

Yablon O., Zaichko N., Reminna I. Indices of Inborn Immunity (TLR2, Interleukins 1 β and 10) in Cases of Pneumonia among Newborn Infants. Journal of Education, Health and Sport. 2017;7(3):519-530. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.439972 http://ojs.ukw.edu.pl/index.php/johs/article/view/4376 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 21.03.2017. Revised 22.03.2017. Accepted: 23.03.2017. Indices of Inborn Immunity (TLR2, Interleukins 1 β and 10) in Cases of Pneumonia among Newborn Infants Olga Yablon, Natalia Zaichko, Inna Reminna National Pirogov Memorial Medical University, Vinnytsya Pirogov St. 56, Vinnytsia, 21018, Ukraine; e-mail: oyablon@gmail.com, biochem {at} vnmu.edu.ua, inna8710@inbox.ru, Abstract The main focus of the article is the problem of neonatal pneumonia diagnosis. Its aim is to examine the state of inborn immunity among mature newborns with pneumonia in terms of TLR2, interleukins 1 β and 10. In the course of the research we have examined 70 mature newborns with pneumonia. As a result of clinical and paraclinic methods of examination, we have obtained the following data: The infection process among half of the children in group I was provoked by the causative agents of toxoplasm, and herpes simplex virus. Patients with acquired pneumonia had hospital contamination twice as often as children with congenital pneumonia. Congenital pneumonia developed among children with low levels of TLR2, while acquired pneumonia developed on the background of TLR2 increase by 3 times in comparison to the children of the control group. Indicators of IL-1 β in the blood serum of children in group I were two times higher than among children of the control group and three times higher among the children of group II. We have also established accurate correlated immediate connection of average level among figures of TLR2 and IL-10 among children of group II (rs=0.4, p<0.05). The connection between the figures of TLR2 and IL-1β, TLR2 and IL-10 depending on the level of CRP is also established. It has been found that there is an accurate reverse connection between the figures of TLR2 and IL-1β, TLR2 and IL-10 among children of group I (rs=-0.36 and rs=-0.56, p<0.05) at CRP level of 6-12 mg/l, as well as a direct connection of average level between the figures of TLR2 and IL-10 (rs=0.32, p<0.05) among children of group I with CRP>24 mg/l. Key words: newborns, pneumonia, TLR2, IL-1 β, IL-10