Add to ORKGSimplified synthetic azinomycins preferentially induce in vitro DNA interstrand cross-links at the same 5'-d(GCC)-3' site as the natural products revealing that non-covalent interactions are relatively unimportant in defining sequence specificity
Actinomycin, echinomycin and [N-Me Cys3 N-Me Cys7] TANDEM bind to double stranded DNA by a sequence ...
AbstractCyanomorpholinoadriamycin (1 μM) was reacted in a transcription buffer with DNA of an initia...
NoThe azinomycins are potent antitumour antibiotics that are able to crosslink DNA, but are relative...
Using a series of synthetic azinomycin analogues, it is shown that the efficiency of in vitro DNA in...
A new set of charges specifically developed for biologically relevant N7-alkylated purine adducts ha...
Nature is a rich source of antitumour agents that can act as a paradigm for the development of synth...
NoThe design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based ...
Mitomycin C, a clinically used chemotherapeutic agent, forms interstrand covalent cross-links in the...
The sequence specificity of the binding of barminomycin (SN-07 chromophore) to DNA was investigated ...
The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based up...
Since the isolation of azinomycins A and B in 1954 from the soil bacterium, Streptomyces sahachiroi...
The azinomycins are potent antitumour antibiotics that are able to crosslink DNA, but are relatively...
In this study we show that the four diastereomers of the azinomycin epoxide (1) have different seque...
AbstractWe have analyzed the specificity of the actinomycin D—DNA interaction. The ‘footprint’ metho...
Not like the rest. In this study we show that the four diastereomers of the azinomycin epoxide (1) h...
Actinomycin, echinomycin and [N-Me Cys3 N-Me Cys7] TANDEM bind to double stranded DNA by a sequence ...
AbstractCyanomorpholinoadriamycin (1 μM) was reacted in a transcription buffer with DNA of an initia...
NoThe azinomycins are potent antitumour antibiotics that are able to crosslink DNA, but are relative...
Using a series of synthetic azinomycin analogues, it is shown that the efficiency of in vitro DNA in...
A new set of charges specifically developed for biologically relevant N7-alkylated purine adducts ha...
Nature is a rich source of antitumour agents that can act as a paradigm for the development of synth...
NoThe design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based ...
Mitomycin C, a clinically used chemotherapeutic agent, forms interstrand covalent cross-links in the...
The sequence specificity of the binding of barminomycin (SN-07 chromophore) to DNA was investigated ...
The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based up...
Since the isolation of azinomycins A and B in 1954 from the soil bacterium, Streptomyces sahachiroi...
The azinomycins are potent antitumour antibiotics that are able to crosslink DNA, but are relatively...
In this study we show that the four diastereomers of the azinomycin epoxide (1) have different seque...
AbstractWe have analyzed the specificity of the actinomycin D—DNA interaction. The ‘footprint’ metho...
Not like the rest. In this study we show that the four diastereomers of the azinomycin epoxide (1) h...
Actinomycin, echinomycin and [N-Me Cys3 N-Me Cys7] TANDEM bind to double stranded DNA by a sequence ...
AbstractCyanomorpholinoadriamycin (1 μM) was reacted in a transcription buffer with DNA of an initia...
NoThe azinomycins are potent antitumour antibiotics that are able to crosslink DNA, but are relative...