Truncated azinomycin analogues intercalate into DNA
- Casely-Hayford, M. A.
- Pors, K.
- Patterson, L. H.
- Gerner, C.
- Neidle, S.
- Searcey, M.
DOIAbstract
The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding. (C) 2004 Elsevier Ltd. All rights reserved
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