Add to ORKGIn order to explain the opposite effect of 6,7-dihydroxylated isomers of 6, 7 - dihydrocanrenone on the urinary sodium and potassium excretion, we have tested the effect of these substances isolated from human urine on the Na(+)-K+ pump from different tissue preparation: rabbit kidney slices as well as NA-K ATPase purified from the kidney. Our results show an inhibition of pump as well as enzyme activity by the 6 beta 7 alpha isomer while the 2 other isomers are either uneffective or slightly stimulating. The 6 beta 7 alpha dihydroxy-6, 7-dihydrocanrenone could be one of the plasma ouabain-like substance incriminated in the pathogenesis of volume-expanded hypertension
Background. Cardiac glycosides have traditionally been used as inotropic agents in the treatment of ...
Specificity of the volume-sensitive sodium pump inhibitor isolated from human peritoneal dialysate i...
Terrestrial animals must conserve water and NaCl to survive dry environments. The kidney reabsorbs 9...
peer reviewedIn order to explain the opposite effect of 6,7-dihydroxylated isomers of 6, 7 - dihydro...
In view of the finding by Mathews et al1 that oneof the circulating Na+, K+-ATPase inhibitors inhuma...
Specificity of the volume-sensitive sodium pump inhibitor isolated from human peritoneal dialysate i...
The effect of salt and/or volume depletion has been tested in 6 end-stage renal disease and 11 essen...
An endogenous sodium pump inhibitor has been purified from human plasma. The purification scheme inv...
The Na/K-ATPase was discovered as an energy transducing ion pump. A major difference between the Na/...
AbstractThe Na/K-ATPase was discovered as an energy transducing ion pump. A major difference between...
The effect of plasma taken from normotensive humans, while on a low and high sodium diet, on [Na + K...
Reports from several laboratories suggest the presence of an ouabainlike compound in plasma and vari...
The purpose of this study was to determine the nephron site, time course, and mechanism of mineraloc...
Semi-purified dog kidney Na+-K+-ATPase was cross-linked with ovalbumin. This immobilized enzyme was ...
SUMMARY We attempted to purify a digitalislike factor from human urine. On the assumption that a nat...
Background. Cardiac glycosides have traditionally been used as inotropic agents in the treatment of ...
Specificity of the volume-sensitive sodium pump inhibitor isolated from human peritoneal dialysate i...
Terrestrial animals must conserve water and NaCl to survive dry environments. The kidney reabsorbs 9...
peer reviewedIn order to explain the opposite effect of 6,7-dihydroxylated isomers of 6, 7 - dihydro...
In view of the finding by Mathews et al1 that oneof the circulating Na+, K+-ATPase inhibitors inhuma...
Specificity of the volume-sensitive sodium pump inhibitor isolated from human peritoneal dialysate i...
The effect of salt and/or volume depletion has been tested in 6 end-stage renal disease and 11 essen...
An endogenous sodium pump inhibitor has been purified from human plasma. The purification scheme inv...
The Na/K-ATPase was discovered as an energy transducing ion pump. A major difference between the Na/...
AbstractThe Na/K-ATPase was discovered as an energy transducing ion pump. A major difference between...
The effect of plasma taken from normotensive humans, while on a low and high sodium diet, on [Na + K...
Reports from several laboratories suggest the presence of an ouabainlike compound in plasma and vari...
The purpose of this study was to determine the nephron site, time course, and mechanism of mineraloc...
Semi-purified dog kidney Na+-K+-ATPase was cross-linked with ovalbumin. This immobilized enzyme was ...
SUMMARY We attempted to purify a digitalislike factor from human urine. On the assumption that a nat...
Background. Cardiac glycosides have traditionally been used as inotropic agents in the treatment of ...
Specificity of the volume-sensitive sodium pump inhibitor isolated from human peritoneal dialysate i...
Terrestrial animals must conserve water and NaCl to survive dry environments. The kidney reabsorbs 9...