Asset variance and covariance are fundamental for financial risk management and many finance applications. With the advent of tick-by-tick high-frequency data, the estimation of univariate variances and multivariate covariance matrices has attracted more attention from econometricians. Many of the proposed high-frequency variance and covariance estimators are based on time-domain measurements. In this thesis, we investigate variance and covariance estimators constructed on the price domain: the price duration based variance and covariance estimators. A price event occurs when the absolute cumulative price change equals or exceeds a pre-specified threshold value. The time taken between two consecutive price events is a price duration. Intuit...