Genome-wide association study identifies multiple risk loci for renal cell carcinoma
- Scelo, Ghislaine
- Purdue, Mark P.
- Brown, Kevin M.
- Johansson, Mattias
- Wang, Zhaoming
- Eckel-Passow, Jeanette E.
- Ye, Yuanqing
- Hofmann, Jonathan N.
- Choi, Jiyeon
- Foll, Matthieu
- Gaborieau, Valerie
- Machiela, Mitchell J.
- Colli, Leandro M.
- Li, Peng
- Sampson, Joshua N.
- Abedi-Ardekani, Behnoush
- Besse, Celine
- Blanche, Helene
- Boland, Anne
- Burdette, Laurie
- Chabrier, Amelie
- Durand, Geoffroy
- Le Calvez-Kelm, Florence
- Prokhortchouk, Egor
- Robinot, Nivonirina
- Skryabin, Konstantin G.
- Wozniak, Magdalena B.
- Yeager, Meredith
- Basta-Jovanovic, Gordana
- Dzamic, Zoran
- Foretova, Lenka
- Holcatova, Ivana
- Janout, Vladimir
- Mates, Dana
- Mukeriya, Anush
- Rascu, Stefan
- Zaridze, David
- Bencko, Vladimir
- Cybulski, Cezary
- Fabianova, Eleonora
- Jinga, Viorel
- Lissowska, Jolanta
- Lubinski, Jan
- Navratilova, Marie
- Rudnai, Peter
- Szeszenia-Dabrowska, Neonila
- Benhamou, Simone
- Cancel-Tassin, Geraldine
- Cussenot, Olivier
- Baglietto, Laura
- Boeing, Heiner
- Khaw, Kay-Tee
- Weiderpass, Elisabete
- Ljungberg, Börje
- Sitaram, Raviprakash T.
- Bruinsma, Fiona
- Jordan, Susan J.
- Severi, Gianluca
- Winship, Ingrid
- Hveem, Kristian
- Vatten, Lars J.
- Fletcher, Tony
- Koppova, Kvetoslava
- Larsson, Susanna C.
- Wolk, Alicja
- Banks, Rosamonde E.
- Selby, Peter J.
- Easton, Douglas F.
- Pharoah, Paul
- Andreotti, Gabriella
- Freeman, Laura E. Beane
- Koutros, Stella
- Albanes, Demetrius
- Mannisto, Satu
- Weinstein, Stephanie
- Clark, Peter E.
- Edwards, Todd L.
- Lipworth, Loren
- Gapstur, Susan M.
- Stevens, Victoria L.
- Carol, Hallie
- Freedman, Matthew L.
- Pomerantz, Mark M.
- Cho, Eunyoung
- Kraft, Peter
- Preston, Mark A.
- Wilson, Kathryn M.
- Gaziano, J. Michael
- Sesso, Howard D.
- Black, Amanda
- Freedman, Neal D.
- Huang, Wen-Yi
- Anema, John G.
- Kahnoski, Richard J.
- Lane, Brian R.
- Noyes, Sabrina L.
- Petillo, David
- Teh, Bin Tean
- Peters, Ulrike
- White, Emily
- Anderson, Garnet L.
- Johnson, Lisa
- Luo, Juhua
- Buring, Julie
- Lee, I-Min
- Chow, Wong-Ho
- Moore, Lee E.
- Wood, Christopher
- Eisen, Timothy
- Henrion, Marc
- Larkin, James
- Barman, Poulami
- Leibovich, Bradley C.
- Choueiri, Toni K.
- Lathrop, G. Mark
- Rothman, Nathaniel
- Deleuze, Jean-Francois
- Mckay, James D.
- Parker, Alexander S.
- Wu, Xifeng
- Houlston, Richard S.
- Brennan, Paul
- Chanock, Stephen J.
DOIAbstract
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1 x 10(-10)), 3p22.1 (rs67311347, P = 2.5 x 10(-8)), 3q26.2 (rs10936602, P = 8.8 x 10(-9)), 8p21.3 (rs2241261, P = 5.8 x 10(-9)), 10q24.33-q25.1 (rs11813268, P = 3.9 x 10(-8)), 11q22.3 (rs74911261, P = 2.1 x 10(-10)) and 14q24.2 (rs4903064, P = 2.2 x 10(-24)). Expression quantitative tr...
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