Background: The sustainability of healthcare systems is a topic of major interest. During periods of economic instability, policy makers typically reallocate resources and execute linear cuts in different areas of public spending, including healthcare. Objectives: The aim of this paper was to examine whether and how per capita public healthcare expenditure (PHE) in the Italian regions was related to the all-cause mortality rate (MR) between 1999 and 2013 and to determine which expenditure item most affected mortality in the short and very short term. Methods: We conducted a pooled cross-sectional time series study. Secondary data were extracted from ‘Health for All’, a database released periodically by the Italian National Institute of Stat...