Pengaruh Avicel PH 102 Terhadap Karakteristik Fisik Dan Laju Disolusi Orally Disintegrating Tablet Piroksikam Dengan Metode Cetak Langsung

The influence of Avicel PH 102 as disintegrant on physical characteristic and dissolutionrate of piroxicam Orally Disintegrating Tablet prepared by direct compressionmethod was observed in this research. Concentration of Avicel PH 102 used were 5%,10%, 15% and 0% as a control. Physical characteristics of the powder blend includingflow rate and angle of repose showed good attributes. The powder blend was pressedinto tablet by hydraulic press with a pressure of 1 ton and diameter of 8 mm. Thephysical characteristic of piroxicam orally disintegrating tablet including hardness,friability, disintegration time, and dissolution rate were examined. The hardness ofall formulas were between 0,99 – 2,78 kP, friability were between 3,45% – 1,25%,disintegration time were between 223,67– 18,33 sec and drug released at 45 minuteswere between 32,71%– 88,63%. The results showed that increasing the concentrationof Avicel PH 102 would increase the hardness, and dissolution rate and decrease thefriability and disintegration time of piroxicam orally disintegrating tablet . Fromstatistical analysis (µ = 0,05), it could be seen that there was significant difference inphysical characteristics and dissolution rate of all formulas. Among all formulas, itcould be concluded that formula with 10% concentration of Avicel PH 102 was theoptimum formul