Comparison Method Wet Granulation and Direct Compression of Physical Properties and Disintegration Time of Orally Disintegrating Tablets Piroxicam

Telah dilakukan penelitian mengenai perbandingan penggunaan metode granulasi basah dan kempa langsung terhadap sifat fisik dan waktu hancur orally disintegrating tablets (ODTs) piroksikam. Penelitian ini bertujuan untuk membandingkan metode pembuatan ODTs piroksikam yang menghasilkan sifat fisik tablet dan waktu hancur yang paling baik. Komposisi formula pada metode granulasi basah dan cetak langsung sama tiap tabletnya yaitu Piroksikam 20 mg, Primellose® 5%, PVP K30 1%, Mg stearat 1%, Manitol 10%, dan Comprecel® ad 175 mg. Tablet ODTs kemudian dievaluasi sifat fisiknya yang meliputi keseragaman bobot, keseragaman ukuran, kekerasan, friabilitas dan friksibilitas, waktu hancur, rasio penyerapan air, waktu pembasahan dan penetapan kadar serta uji disolusi. Hasil penelitian menunjukkan bahwa kedua metode menghasilkan sifat fisik tablet yang baik. Namun metode kempa langsung memberikan waktu hancur yang lebih cepat yaitu 55,51 detik dibandingkan dengan metode granulasi basah. Hasil uji statistik menggunakan metode independent sample T test menunjukkan terdapat perbedaan bermakna waktu hancur (P<0,05) antara formula dengan metode kempa langsung dengan granulasi basah.Study on comparison of wet granulation and direct compression method of physical properties and disintegration time of orally disintegrating tablets piroxicam has been done. This study aims to comparison which method gives better results of physical properties and disintegration time between wet granulation and direct compression method. Both methods are made with the same composition formula of each tablets is Piroxicam 20 mg, Primellose® 5%, 1% PVP K30, magnesium stearate 1%, Mannitol 10%, and Comprecel® up to 175 mg. ODTs then evaluated physical properties which include weight variation, thickness, hardness, friability and friksibility, disintegration time, ratio of water absorption, wetting time, drug content and dissolution test. The results showed that both methods produce the physical properties of a good tablets. However, the method of direct compression provides a disintegrating faster 55.51 seconds compared with the wet granulation method. Statistical test using independent sample T test showed that there were significant differences in the disintegration time (P