Z.: Pharmacology of Vasodepressor Compounds Structurally Related to Sympathomimetic Amines

Konzett (1) has described the pharmacology of several N-alkyl homologues of epinephrine and reports that some of these, in suitable dose, cause a marked fall in blood pressure, although they retain many of the other pharmacologic actions of epinephrine. He also mentions the isopropyl homologues of ‘Sym-patol ’ (1-(p-hydroxyphenyl)-2-isopropylaminoethanol) and ‘Neo-Synephrine’ (1-m-(hydroxyphenyl)-2-isopropylaminoethanol), but does not describe their effect on blood pressure. We have carried out in this Laboratory an investiga-tion of the pharmacologic actions of these two latter substances and of various other structurally related compounds. The synthesis of some of these corn-pounds has been described by Corrigan, Langerman and Moore (2). The pharmacologic results obtained are described in this communication. 1. EFFECT ON BLOOD PRESSURE. Carotid blood pressure was determined in dogs anesthetized with sodium pentobarbital. All injections were made into the exposed femoral vein. Average results obtained are shown in table 1. It should be noted that tyramine (1-(p-hydroxyphenyl)-2-arninoethane) is th