COMPARISON OF PRESSOR ACTION OF ALIPHATIC AMINES

The resemblance of aliphatic to aromatic amines in raising blood pressure has been repeatedly observed and reviewed (1-4). Recently, there has been a renewal of interest in those aliphatic amines which have not been studied before (5-7). Indeed, certain compounds are suitable for clinical use (8-9). Pharma-cological studies on other newer products have also been reported (10-11). The present investigation concerns a comparison of the pressor activity of thirty-nine aliphatic amines, prepared by Dr. E. Rohrmann and Mr. H. A. Shonle of our own laboratories. PROCEDURE AND RESULTS. As before (12-13), experiments were carried out in pithed dogs. The animals, 176 in number, weighed from 5.1 to 11.8 kg., averaging 7.5 kg. It was soon disclosed that the majority of the aliphatic amines caused tachyphylaxis after the first intravenous injection. It was, therefore, necessary to evaluate the pressor action of various substances in individual dogs with epinephrine as a standard. Comparisons were made only with reference to the intensity of action; namely, the peak of rise of each amine was matched with that of a suitable dose of epinephrine chloride. Groups of 3 to 8 dog