Add to ORKGNew 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective agents on a human neuroblastoma (SH-SY5Y) cells model. They inhibited at low micromolar concentrations the oxidative damage and the death induced by exposure to hydrogen peroxide. These heteroarylnitrones showed excellent peroxyl free radical absorbance capacities, analyzed by oxygen radical absorbance capacity (ORAC) assay with fluorescein as the fluorescent probe, ranging from 1.5- to 16.5-fold the value of the reference nitrone, R-phenyl-N-tert-butylnitrone (PBN). The electron spin resonance spectroscopy (ESR) demonstrated the ability of these derivatives to directly trap and stabilize oxygen, carbon, and sulfur-centered free radicals. Th...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective...
New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective...
A new series of heteroaryl nitrones, 1–7, bearing furoxanyl and thiadiazolyl moieties, were evaluate...
A new series of heteroaryl nitrones, 1–7, bearing furoxanyl and thiadiazolyl moieties, were evaluate...
The imbalance between intracellular reactive oxygen species (ROS) and the cells’ antioxidant defence...
The reactions of nitrones with free radicals have been widely studied both in vitro and in vivo. In ...
From an in-house library of compounds, five phenothiazines and one dibenzothiadiazepine were select...
Le stress oxydant est associé à de nombreuses pathologies humaines telles que les maladies neurodégé...
Herein, we report the synthesis and neuroprotective power of some N-substituted C-(dialkoxy)phosphor...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective...
New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective...
A new series of heteroaryl nitrones, 1–7, bearing furoxanyl and thiadiazolyl moieties, were evaluate...
A new series of heteroaryl nitrones, 1–7, bearing furoxanyl and thiadiazolyl moieties, were evaluate...
The imbalance between intracellular reactive oxygen species (ROS) and the cells’ antioxidant defence...
The reactions of nitrones with free radicals have been widely studied both in vitro and in vivo. In ...
From an in-house library of compounds, five phenothiazines and one dibenzothiadiazepine were select...
Le stress oxydant est associé à de nombreuses pathologies humaines telles que les maladies neurodégé...
Herein, we report the synthesis and neuroprotective power of some N-substituted C-(dialkoxy)phosphor...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...
International audienceIn this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN...