R: The influence of indomethacin on the pharmacokinetics, diuretic response and hemodynamics of furosemide in the dog. J Pharmacol Exp Ther 206

of indomethacin on the pharmacokinetics, di-uretic response and hemodynamics of furosem-ide in the dog. J. Pharmacol. Exp. Ther. 206: 431-438, 1978. Indomethacin has the potential to interact with furosemide in a number of different fashions. We have investigated some ofthese possibilities in seven mongrel dogs that received furosemide (2 mg/kg i.v.). Plasma and urinary concentra-tions of furosemide were measured by high per-formance liquid chromatography, diuretic re-sponse was assessed by urinary sodium excre-tion and renal blood flow and its distribution were estimated using the radioactive micro-sphere technique. Furosemide induced