L#{246}ffler’s Endomyocardial Fibrosis With Eosinophilia in Association With Acute Lymphoblastic Leukemia

The association of eosinophilia and L#{246}f- tion of remission. It is suggested that the fier’s endomyocardial fibrosis with acute eosinophilia in this case was not “eosino-lymphoblastic leukemia in a 9-yr-old boy philic leukemia, ” but more likely a non-is reported. During the illness, there were neoplastic response to an antigenic stimu-three leukemic relapses, each preceded by lus from the leukemic process. eosinophilia which subsided upon induc-T HE TERM eosinophilic leukemia has been applied broadly to a group of disorders associated with circulating eosinophilia, ’ and the association of this syndrome with cardiomegaly, congestive failure, and L#{246}ffier’s endomyo-cardial fibrosis is now well recognized.2’3 Opinion has not been uniform that this syndrome is indeed a form of leukemia. In fact, there has been constant controversy and confusion over this issue since “eosinophilic leukemia ” was first described 60 yr ago.4 The purpose of this report is to describe a boy with typical acute lympho-blastic leukemia and associated eosinophilia and endomyocardial fibrosis. Be-cause the leukemia was of lymphoid origin and because eosinophilia preceded each leukemic relapse, it is suggested that the eosinophilia was reactive and not neoplastic