CASE REPORTS Endomyocardial Disease and Eosinophilia Report of a Case

SUMMARY While an association between blood eosinophilia and endomyocardial disease has been recognized, the role of the eosinophil in the pathogenesis of the cardiac lesions remains uncer-tain. In a 69-year-old man with large cell carcinoma of the lung, marked eosinophilia was stimulated by and progressed with the course of the neoplasm which was producing an eosinophil chemotac-tic factor. Peripheral blood eosinophils were vacuolated and degranulated while those in the bone marrow were morphologically SINCE 1893, when Reinbach first described a right ventric-ular endocardial mural thrombus in a patient with eosinophilia,1 the association between blood eosinophilia and endomyocardial disease has been recognized in various clinical entities including Loffler's endocarditis parietalis fibroplastica,2 Davies ' African endomyocardial fibrosis,3 eosinophilic leukemia,4 and eosinophilic collagen disease.