Editorial Prostaglandin E2 in Remote Control of Myocardial Remodeling

Despite the advance in treatment of acute myocardial infarc-tion (MI) with timely reperfusion of ischemic myocardi-um, coronary artery disease remains a leading cause of morbid-ity and mortality worldwide. In patients who have survived acute MI, the heart undergoes a remodeling process characterized by changing in size, shape, structure, and function. The progres-sive ventricular dilation, wall thinning, and fibrosis, together with loss of contractile function, lead to life-threatening heart failure and arrhythmia. Therefore, understanding the process of pathological remodeling in post-MI hearts is of paramount importance. Article see p 2904 It is well established that inflammatory response is elicited by MI and contributes significantly to cardiac remodeling. At the onset of MI injury, inflammatory leukocytes produced in bone marrow are mobilized and infiltrate the myocardiu