Editorial A translational approach to myocardial remodelling

The concept of cardiac remodelling was initially created to describe the changes in the anatomy of the left ventricle that occur following myocardial infarction.1 Todaymyocardial remodelling is used to qualify a variety of changes in the bio-physiology of the cardiomyocyte, the volume and composition of cardiomyocyte, and non-cardiomyocyte compartments, and the geometry and architecture of the left ventricular chamber that occur in response to myocardial infarction, pressure or volume overload, cardiomyopathic states, and exposure to infectious or cardiotoxic agents.2 Myocardial remodelling results from modifications that are not necessarily adaptive to the initial insult, but patho-logical and potentially self-perpetuating in a progressive vicious circle. In addition, the effects of the insult on the final phenotype are modulated by several interferin