ORAL PRESENTATION Open Access Management of precocious puberty Toshiaki Tanaka From 7th APPES Biennial Scientific Meeting

The objectives of treatment for children with central pre-cocious puberty (CPP) are to avoid psychosocial problems caused by early pubertal development and to normalize adult height (AH). A long-acting GnRH analog is the treatment of choice for CPP. GnRH analog administration effectively arrests further development of secondary sex characteristics, slows bone age (BA) maturation, increases pubertal height gain, and is believed to eventually improve AH prognosis. However, the improvement of AH is not well established. It is reported that GnRH analog is effec-tive to improve adult height only in early onset (girls <6 years) CPP [1]. Although BA maturation is decelerated by suppressing gonadotropins with GnRH analog and puber-tal period is elongated, growth rate diminishes due to sup-pressed sex steroid hormone and, in part due to decrease