Gonadotropin Releasing Hormone Increase Final Stature in Children W A

Abstract: In the setting of central precocious puberty (CPP), the motivation for hormonal intervention is to help the child to reach a taller adult stature than she would achieve otherwise. While gonadotropin-releasing hormone analogs (GnRHa) constitute an established treatment for improving adult stature in girls presenting with CPP up to age 6 (true precocious puberty), it is not yet clear whether or not the same is true in the setting of CPP presented in girls beyond age 6 (advance puberty). GnRHa may slow growth velocity, offsetting the anticipated improve-ment in final height that should have resulted from the increased time before growth plate fusion. Consequently, it’s been suggested that growth hormone (GH) should be combined with GnRHa to improve the results Few c GnRHa in expert op studies we hormone analogue.’ process yi meta-anal with and w A sign adult heig However, standard