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Abbreviations used in this paper: ADLD, adult-onset autosomal dominant leu-kodystrophy; AT, ataxia telangiectasia; CNS, central nervous system; HGPS, Hutchinson-Gilford progeria syndrome; hTERT, human TERT; PD, population doubling; qRT-PCR, quantitative RT-PCR; SA--gal, senescence-associated -galactosidase; TERT, telomerase reverse transcription; TIF, telomere dysfunction