Cell CyCle News & Views www.landesbioscience.com Cell Cycle 179

Both cancer cells and aging cells exhibit altered metabolic activity, which is, at least in part, due to deregulation of the p53 fam-ily members. Although several mechanisms through which p53 affects metabolisms are known, less information is available of its fam-ily member p73. in the December 15, 2013 issue of Cell Cycle, Velletri et al.1 report the abil-ity of TAp73 to bind the promoter and regulate the expression of glutaminase type 2 (Gls2). in particular, the authors investigate the regu-lation of the TAp73/Gls2 axis during the in vitro differentiation of neuroblastoma cells and cortical neurons, including during mouse cerebellar development